Alison L. Allan's Cancer Stem Cells in Solid Tumors (Stem Cell Biology and PDF

By Alison L. Allan

ISBN-10: 1617792454

ISBN-13: 9781617792458

ISBN-10: 1617797588

ISBN-13: 9781617797583

The “cancer stem phone” speculation postulates that melanoma arises from a subpopulation of tumor-initiating cells or melanoma stem cells (CSCs). whereas the belief of melanoma stem cells has been round for greater than 100 years, proof from the fields of hematology and melanoma biology has now verified the severe function of stem cells in hematological malignancies and instructed that those related mechanisms also are principal to the initiation, development, and remedy of good cancers. scientific and experimental stories have proven that CSCs show many classical houses of ordinary stem cells, together with a excessive self-renewal means and the power to generate heterogeneous lineages; the requirement for a particular “niche”/microenvironment to develop; and an elevated potential for self-protection opposed to harsh environments, pollution, and medication.

 

Cancer Stem Cells in reliable Tumors represents an in depth evaluation of melanoma stem cells and their position in reliable cancers. produced from 24 chapters, this quantity will offer readers with a finished knowing of this significant and evolving field.

 

Topics coated include:

  • Introduction of the CSC hypothesis
  • Historical views and the contributing classes from leukemia
  • Current wisdom in regards to the identity and position of CSCs in a number of kinds of strong melanoma together with breast, mind, colorectal, pancreatic, prostate, cancer, lung, ovarian, hepatocellular, and head and neck melanoma
  • Molecular pathways focused on using CSC functionality, with a selected concentrate on the radical convergence of embryonic and tumorigenic signaling pathways
  • In vitro and in vivo assays, version platforms, and imaging modalities for learning CSCs
  • The scientific significance of CSCs for melanoma administration and therapy, together with vital implications for analysis, prediction, and remedy resistance
  • Consideration of the debate surrounding the CSC speculation and demanding unanswered questions during this field

 

This collective paintings was once written through a gaggle of in demand foreign specialists in melanoma biology, oncology, and/or stem mobile biology. it's going to function a useful source for confirmed researchers, professors, overall healthiness care pros, and scholars within the scientific and clinical neighborhood who're investigating stem cells and/or oncology.

Show description

Read or Download Cancer Stem Cells in Solid Tumors (Stem Cell Biology and Regenerative Medicine) PDF

Similar cell biology books

Kathleen Collins's Tetrahymena Thermophila (Methods in Cell Biology) PDF

This new quantity of tools in telephone Biology appears at Tetrahymena thermophila, a version organism in experimental biology. Covering sections on platforms views and working ideas, chapters are written through specialists within the box. With innovative material, this accomplished assortment is meant to guide researchers of Tetrahymena thermophila for future years.

Hajime Wada,Norio Murata's Lipids in Photosynthesis: Essential and Regulatory PDF

Lipids in Photosynthesis: crucial and Regulatory features, presents a vital precis of an exhilarating decade of study on relationships among lipids and photosynthesis. The ebook brings jointly largely cross-referenced and peer-reviewed chapters through favourite researchers. the subjects lined comprise the constitution, molecular association and biosynthesis of fatty acids, glycerolipids and nonglycerolipids in vegetation, algae, lichens, mosses, and cyanobacteria, in addition to in chloroplasts and mitochondria.

Download e-book for kindle: TH17 Cells in Health and Disease by Shuiping Jiang

“About 25 years in the past, Mosmann & Coffman brought the TH1 / TH2 paradigm of T helper phone differentiation which helped clarify many elements of adaptive immunity from getting rid of intracellular as opposed to extracellular pathogens to induction of other sorts of tissue irritation. even if, TH1 / TH2 paradigm couldn't properly clarify improvement of yes inflammatory responses which supplied impetus for the invention of a brand new subset of T cells referred to as TH17 cells.

Get Studies on Renal Disorders (Oxidative Stress in Applied PDF

Stipulations reminiscent of oxidative tension and hypoxia, that have a generalized effect at the oxygen metabolism, were implicated within the genesis of kidney affliction. which means deepening our figuring out of the pathobiology of oxygen metabolism in such ailments can be a fruitful course in the direction of tangible medical merits.

Additional resources for Cancer Stem Cells in Solid Tumors (Stem Cell Biology and Regenerative Medicine)

Example text

Download PDF sample

Cancer Stem Cells in Solid Tumors (Stem Cell Biology and Regenerative Medicine) by Alison L. Allan


by Brian
4.1

Rated 4.20 of 5 – based on 6 votes