By Alison L. Allan
The “cancer stem phone” speculation postulates that melanoma arises from a subpopulation of tumor-initiating cells or melanoma stem cells (CSCs). whereas the belief of melanoma stem cells has been round for greater than 100 years, proof from the fields of hematology and melanoma biology has now verified the severe function of stem cells in hematological malignancies and instructed that those related mechanisms also are principal to the initiation, development, and remedy of good cancers. scientific and experimental stories have proven that CSCs show many classical houses of ordinary stem cells, together with a excessive self-renewal means and the power to generate heterogeneous lineages; the requirement for a particular “niche”/microenvironment to develop; and an elevated potential for self-protection opposed to harsh environments, pollution, and medication.
Cancer Stem Cells in reliable Tumors represents an in depth evaluation of melanoma stem cells and their position in reliable cancers. produced from 24 chapters, this quantity will offer readers with a finished knowing of this significant and evolving field.
Topics coated include:
- Introduction of the CSC hypothesis
- Historical views and the contributing classes from leukemia
- Current wisdom in regards to the identity and position of CSCs in a number of kinds of strong melanoma together with breast, mind, colorectal, pancreatic, prostate, cancer, lung, ovarian, hepatocellular, and head and neck melanoma
- Molecular pathways focused on using CSC functionality, with a selected concentrate on the radical convergence of embryonic and tumorigenic signaling pathways
- In vitro and in vivo assays, version platforms, and imaging modalities for learning CSCs
- The scientific significance of CSCs for melanoma administration and therapy, together with vital implications for analysis, prediction, and remedy resistance
- Consideration of the debate surrounding the CSC speculation and demanding unanswered questions during this field
This collective paintings was once written through a gaggle of in demand foreign specialists in melanoma biology, oncology, and/or stem mobile biology. it's going to function a useful source for confirmed researchers, professors, overall healthiness care pros, and scholars within the scientific and clinical neighborhood who're investigating stem cells and/or oncology.
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Cancer Stem Cells in Solid Tumors (Stem Cell Biology and Regenerative Medicine) by Alison L. Allan